منابع مشابه
Force-induced DNA slippage.
DNA containing repetitive sequences displays richer dynamics than heterogeneous sequences. In the genome the number of repeat units of repetitive sequences, known as microsatellites, may vary during replication by DNA slippage and their expansion gives rise to serious disorders. We studied the mechanical properties of repetitive DNA using dynamic force spectroscopy and found striking difference...
متن کاملDynamics of force-induced DNA slippage.
We study the base pairing dynamics of DNA with repetitive sequences where local strand slippage can create, annihilate, and move bulge loops. Using an explicit theoretical model, we find a rich dynamical behavior as a function of an applied shear force f: reptationlike dynamics at f=f(c) with a rupture time tau scaling as N3 with its length N, drift-diffusion dynamics for f(c)<f<f(*), and a dyn...
متن کاملDynamic aspects of DNA DNA-slippage and nucleosome dynamics
xi 1. Properties of DNA 1 1.1. The structure of DNA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2. Thermodynamics of DNA . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.2.1. Binding free energies of double stranded DNA . . . . . . . . . . . . 4 1.2.2. Denaturation of long DNA molecules . . . . . . . . . . . . . . . . . 5 1.2.3. DNA melting of homogenous sequences . ....
متن کاملPlastome mutator-induced alterations arise in Oenothera chloroplast DNA through template slippage.
The plastome mutator of Oenothera hookeri strain Johansen causes deletions and duplications at target sites defined by direct repeats in the plastid genome. Previous studies characterized the mutations long after they had occurred and could not discriminate between the possibilities that the plastome mutator acted through unequal homologous recombination or template slippage. From the known hot...
متن کاملDeletion mutations caused by DNA strand slippage in Acinetobacter baylyi.
Short nucleotide sequence repetitions in DNA can provide selective benefits and also can be a source of genetic instability arising from deletions guided by pairing between misaligned strands. These findings raise the question of how the frequency of deletion mutations is influenced by the length of sequence repetitions and by the distance between them. An experimental approach to this question...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2007
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.095836